Centuries ago, cannabis was widely used in ancient Indian, Chinese, Egyptian, and Islamic cultures for medicinal purposes. However, the Single Convention on Narcotic Drugs deemed cannabis as an illegal drug back in 1961. Originally, the treaty intended to cover drugs such as opium, coca, and others such as morphine, heroin, and cocaine. Unfortunately, cannabis was classified under the group of narcotics because of its psychoactive effects. However, the convention does recognize the medical use and research of certain drugs. Typically, drugs such as opioids are heavily prevalent within medical institutions as they are primarily used to treat moderate to severe chronic pain. However, extensive research has suggested that cannabis can be an effective alternative to opioids. Moreover, researchers have also linked cannabis to effectively treating a variety of medical conditions such as cancer, depression, arthritis, MS, AIDS, Alzheimer’s, and Tourette’s. Due to the psychoactive effect of cannabis, most countries have moved to adopt medicinal cannabis legislation. However, studies have discovered that the psychoactive effect is derived from cannabis’ THC compound, which is predominantly found within the marijuana family. On the other hand, the hemp family, which also falls under the cannabis family, primarily contains CBD. Hemp generally contains very minimal traces of THC but contains much more CBD, making its psychoactive effects negligible. While the two compounds differ in their biological makeup, they offer similar therapeutic benefits. As a result, CBD adoption is growing significantly around the world. In particular, countries such as Argentina, Brazil, Canada, Colombia, Germany, Italy, Mexico, the United Kingdom, and the U.S. have all moved to allow a form CBD-based medical cannabis products use. According to data compiled by IMARC Group, the medical cannabis market was estimated to reach USD 13.4 Billion in 2018. By 2024, the market is projected to reach the value of USD 44.4 Billion while exhibiting a CAGR of 22.9% from 2019 to 2024. Pressure BioSciences, Inc. (OTC:PBIO), Zynerba Pharmaceuticals, Inc. (NASDAQ:ZYNE), Charlotte’s Web Hldgs Inc. (OTC:CWBHF) (CNSX:CWEB.CN), Sorrento Therapeutics, Inc. (NASDAQ:SRNE), The Green Organic Dutchman Holdings Ltd. (OTC:TGODF) (TSX:TGOD.TO).
Research has suggested that cannabis is a much safer alternative in comparison to other treatment options, which often include opiods. Moreover, cannabis can be used in combination with other treatments to either enhance their effects or even combat negative side effects. For instance, cannabis is highly effective in reducing nausea and suppressing pain among chemotherapy patients while also stimulating their appetite. Similarly, cannabis is also used in combination with opioids, which enables patients to reduce their opioid dosage amount and frequency. As the market continues to develop, more patients are transitioning towards consuming edibles and oils over traditional flower as cannabis extracts and edibles are preferred among patients because they are typically more concentrated, delivering a more potent effect. Furthermore, a steadily rising aging population is also playing a large role within the medical cannabis industry. As a result, doctors are beginning to lean towards prescribing cannabis over traditionally prescribed medications if medical cannabis is legal in the region. “Least controversial is the extract from the hemp plant known as CBD (which stands for cannabidiol) because this component of marijuana has little, if any, intoxicating properties. CBD-dominant strains have little or no THC, so patients report very little if any alteration in consciousness,” said Peter Grinspoon, M.D., a physician in Boston and Massachusetts General Hospital, “Many patients find themselves in the situation of wanting to learn more about medical marijuana, but feel embarrassed to bring this up with their doctor. My advice for doctors is that whether you are pro, neutral, or against medical marijuana, patients are embracing it, and although we don’t have rigorous studies and “gold standard” proof of the benefits and risks of medical marijuana, we need to learn about it, be open-minded, and above all, be non-judgmental.”
Pressure BioSciences, Inc. (OTCQB:PBIO) announced earlier last month that it had, “released a new, short video demonstrating the ability of the Company’s proprietary Ultra Shear Technology (UST(TM)) platform to create water-soluble CBD oil that disperses instantly, resulting in improved dosing effectiveness, enhanced absorption, and more aesthetically-pleasing products when added to carbonated soft drinks, vitamin-infused sports drinks, and beer.
Link to video: https://www.youtube.com/watch?v=gAqFQmsGHcA
In addition to superior aesthetic quality, the Company believes the resulting low nanometer-scale emulsions (“nanoemulsions”) of UST-processed CBD oil should also result in optimized and reproducible bodily absorption, bioavailability, and dosing safety for CBD oil and other UST-processed materials, when compared to many of the processed CBD oils and products that are commercially available today.
Mr. Edgar Ward, President and CEO of NutraLife Biosciences (OTCQB:NLBS), said: ‘NutraLife manufactures and sells NUTRAHEMPCBD, a line of CBD-infused products that includes creams, sprays, and other products that support daily health and wellness uses. We strive to ensure that our CBD-infused products will always be of the highest quality possible; therefore, we are constantly looking for advanced technologies to continue to improve our manufacturing processes. After reviewing available data and PBI’s videos, we believe methods like PBI’s UST platform may enable us to offer products with superior quality and effectiveness.’
CBD is a non-psychoactive, oil-soluble compound extracted from the cannabis plant, and is typically marketed dissolved in plant oil. It has been widely reported to offer numerous health benefits from stress and anxiety relief, to decreased muscle, joint, cancer and other pain, reduced inflammation, and to nearly miraculous relief of persistent seizures. However, because CBD is an oil-based product, its ingestion typically results in poor absorption in water-based living systems. There has been enormous interest in the development of truly water-soluble CBD, to achieve efficient absorption and bioavailability from foods and beverages. The market for CBD beverages alone could achieve revenue of $260 million in just the U.S. by2022 (Bloomberg, September 27, 2018) and much more world-wide. Unfortunately, because of solubility issues, many CBD products on the market today contain an inefficient over-abundance of CBD and/or undesirable chemicals to improve and stabilize its solubility in water. PBI believes that all of these beverages and other CBD-based products could substantially benefit from PBI’s Ultra Shear Technology platform, to achieve water solubility and stability from the physics of high-pressure shearing – rather than from dependency upon chemistry and reliance upon use of undesirable chemicals.
Dr. Brad Young, Chief Commercial Officer of PBI, commented: ‘We are very pleased to now show (in this follow-up video) the ability of our proprietary UST platform to mix CBD oil in water and infuse carbonated soft drinks, vitamin-infused sport drinks, and beer. This latest video further highlights the power of our UST platform to make nanoemulsions and its potential to help nutraceutical and beverage manufacturers make high-quality, oil-based products. With such compelling results to rely on, and with numerous opportunities ahead of us, we intend to accelerate the development of our UST platform to better address what we believe are several multi-billion-dollar markets in nutraceuticals, cosmetics, and food & beverages.’
About Pressure BioSciences, Inc: Pressure BioSciences, Inc. (OTCQB:PBIO) is a leader in the development and sale of innovative, broadly enabling, pressure-based solutions for the worldwide life sciences industry. Our products are based on the unique properties of both constant (i.e., static) and alternating (i.e., pressure cycling technology, or PCT) hydrostatic pressure. PCT is a patented enabling technology platform that uses alternating cycles of hydrostatic pressure between ambient and ultra-high levels to safely and reproducibly control bio-molecular interactions (e.g., cell lysis, biomolecule extraction). Our primary focus is in the development of high pressure-based products for biomarker and target discovery, drug design and development, biotherapeutics characterization and quality control, food science, soil & plant biology, forensics, and counter-bioterror applications. Additionally, we are actively expanding the use of our pressure-based technologies in the following areas: (1) the use of our recently acquired protein disaggregation and refolding technology from BaroFold, Inc. to allow entry into the biologics manufacturing and contract research services sector, and (2) the use of our recently-patented, scalable, high-efficiency, pressure-based Ultra Shear Technology (UST(TM)) platform to (i) create stable nanoemulsions of otherwise immiscible fluids (e.g., oils and water) and to (ii) prepare higher quality, homogenized, extended shelf-life or room temperature stable low-acid liquid foods that cannot be effectively preserved using existing non-thermal technologies.”
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Zynerba Pharmaceuticals, Inc. (NASDAQ:ZYNE) is the leader in pharmaceutically-produced transdermal cannabinoid therapies for rare and near-rare neuropsychiatric disorders. Zynerba Pharmaceuticals, Inc. recently announced that the U.S. Food and Drug Administration (FDA) had granted Fast Track Designation for the Company’s lead development candidate Zygel(TM) (ZYN002 CBD gel) for treatment of behavioral symptoms associated with Fragile X Syndrome (FXS). FDA’s Fast Track program is designed to facilitate the development of drugs intended to treat serious conditions and fill unmet medical needs and can lead to expedited review by FDA in order to get new important drugs to the patient earlier. Zygel (CBD gel) is the first and only pharmaceutically-manufactured CBD formulated as a patent-protected permeation-enhanced clear gel, designed to provide controlled drug delivery into the bloodstream transdermally (i.e. through the skin). Recent studies suggest that FXS and other neuropsychiatric conditions may be associated with a disruption in the endocannabinoid (EC) system. “The FDA’s decision to grant Fast Track Designation for Zygel underscores the significance and severity of the unmet medical need that exists for patients living with Fragile X Syndrome and their caregivers,” said Armando Anido, Chairman and Chief Executive Officer of Zynerba. “We believe that Zygel has the potential to be the first treatment indicated to directly address the core behavioral symptoms of this syndrome, and we look forward to working closely with the FDA to obtain approval to market Zygel as soon as possible.”
Charlotte’s Web Hldgs Inc. (OTCQX:CWBHF) (CNSX:CWEB.CN) is the market leader in the production and distribution of innovative hemp-based cannabidiol wellness products. Charlotte’s Web Holdings, Inc. recently reported its 2018 harvested hemp results. The Company reported more than a 10 times growth in harvested hemp compared to its 2017 grow season. The high-quality 100% U.S.-grown hemp will be processed through proprietary extraction methods to create whole plant hemp extract that will be used in Charlotte’s Web products for sale in 2019 and 2020. “Charlotte’s Web is one of only a few hemp CBD producers capable of supplying large volumes of high-quality hemp extract from its own supply chain that can meet significantly increasing market demand,” said Hess Moallem, President and Chief Executive Officer of Charlotte’s Web. “As the category and brand leader, our goal is to increase our market share and with this bountiful harvest we are able to satisfy our customer demands for 2019 and beyond. This incredible harvest ensures we can continue to produce our high-quality human nutrition products without being subject to constantly fluctuating market prices as is common with third-party sourced raw material. This allows us to have better control and predictability over our cost of goods sold and thereby our gross margins. In addition, these harvest levels will allow us to explore opportunities to supply future partners with our proprietary hemp extracts.”
Sorrento Therapeutics, Inc. (NASDAQ:SRNE) is a clinical stage, antibody-centric, biopharmaceutical company developing new therapies to turn malignant cancers into manageable and possibly curable diseases. Sorrento Therapeutics, Inc. recently announced that it had established a new business unit to focus on the market potential for its innovative water-soluble cannabidiol (CBD) formulation technology. Cannabidiol (CBD) has been under consideration within the pharmaceutical side of Sorrento for its interesting pharmacological properties and potential clinical benefits in multiple central nervous system, autoimmune or inflammatory disease and pain related indications. “Without distracting from our pharmaceutical business, we have the ability to leverage another Sorrento innovative technology – this time from our formulation experts – and make it available to the broader consumer market,” stated Dr. Henry Ji, Chief Executive Officer and Chairman of Sorrento Therapeutics. “Longer-term, we may consider spinning off our CBD consumer business into an independently operated company if appropriate, while our research and clinical development team continues to explore the potential pharmaceutical applications of cannabidiol (CBD) for the medical markets.”
The Green Organic Dutchman Holdings Ltd. (OTCQX:TGODF) (TSX:TGOD.TO) is a research & development company licensed under the Access to Cannabis for Medical Purposes Regulations (“ACMPR”) to cultivate medical cannabis. The Green Organic Dutchman Holdings Ltd. recently announced it had signed a definitive agreement to acquire 100% of the issued and outstanding shares of privately-held HemPoland in an immediately accretive cash and share transaction. HemPoland is a leading European manufacturer and marketer of premium organic CBD oils led by founder and CEO, Maciej Kowalski, one of Europe’s most widely recognized CBD experts. This strategic acquisition provides access to HemPoland’s vast distribution network, premium Cannabigold brand, state-of-the-art hemp oil extraction technologies, and provides a strategic pathway into the European market for TGOD’s medical & recreational products and licensing deals. “HemPoland is a key component to a number of strategic acquisitions and planned partnerships focused on expanding our global distribution network. This acquisition will significantly add to the Company’s top and bottom line,” said Brian Athaide, Chief Executive Officer of TGOD. “Gaining market share with CBD products now, in the EU, with over 700 locations allows TGOD to establish immediate brand awareness across all verticals including infused beverages. This is an accretive acquisition and gateway to Europe’s 750 million people accelerating our plan of becoming the world’s largest organic cannabis brand,” continued Athaide.
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